Metabolic reprogramming is a hallmark of both cancer and immune cells, shaping their function, survival, and interactions within the tumor microenvironment. Our research investigates how tumors exploit metabolic pathways to sustain their growth and evade immune surveillance, while also examining how immune cell metabolism influences anti-tumor responses. Using single-cell transcriptomics, genome-scale metabolic models, and computational-experimental approaches, we aim to uncover key metabolic vulnerabilities that could be targeted to enhance immunotherapy efficacy. By deciphering these metabolic interactions, we seek to develop novel strategies to rewire immune cell function and overcome tumor-driven immunosuppression.