Genotype-phenotype relations in cancer at the single-cell level
Tumors consist of cancer clones that are genetically and transcriptionally different from one another. This heterogeneity has shown to play a crucial role in tumor development and its response to treatment. We work on developing computational methods for inferring both the genetic alterations and the transcriptional cellular state at the single-cell level. This information is then used for linking the cell’s genotype to its phenotype, addressing questions related to cancer development and resistance to treatment.