Genotype-phenotype relations in cancer at the single-cell level

The Tumor Genomic Landscape and Its Impact on Cancer Immunity

Understanding the genomic architecture of tumors is key to unraveling their interactions with the immune system. Our research focuses on characterizing tumor-intrinsic genomic features—including mutations, copy number alterations, and transcriptomic signatures—that shape immune responses within the tumor microenvironment. By integrating multi-omics data with computational modeling, we aim to identify genetic determinants of immune evasion, tumor immunogenicity, and response to immunotherapy. This knowledge provides a foundation for predicting patient outcomes and designing personalized therapeutic strategies that enhance anti-tumor immunity.

tumor_genomics